Tylenol's Impact on Glutathione and Liver Damage Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol is just poison. , Dr. Stanton Hom explains how a simple over the counter drug can deplete glutathione, dysregulate detox, and show up in the literature as a risk factor for autism, asthma, Acetaminophen metabolism Tylenol And Glutathione Invigor Medical