Acetaminophen (Tylenol) Use in Pregnancy: Autism Concerns YouTube Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram