Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Frontiers Manipulations of Glutathione Metabolism Modulate IP3 Mediated Store Operated Ca2+ Entry on Astroglioma Cell Line Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells Cellular & Molecular Immunology Mast Cells British Society for Immunology Amazon.com: Wellness Resources Quercetin Phytosome 250 mg with Luteolin 100 mg, Mast Cell Stabilizer & Natural Histamine Support for Seasonal Allergies, NAD Support and Neuroprotective Supplement (60 Capsules) : Health & Household