Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Mast cell activators. MC = mast cell; LMWM = low molecular weight Download Scientific Diagram Did you know one single mast cell can release chemicals that affect your skin, gut, heart, brain, and immune system all at once? That's why MCAS can feel so overwhelming, the IRE1 determines ferroptosis sensitivity through regulation of glutathione synthesis Nature Communications Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies?