I'm Dr Ashley Mayer . I'm a practicing integrative physician, and also a mama to two great kiddos of my own! If you caught my post on Ibuprofen a few days ago, Tylenol's Impact on Glutathione and Liver Damage Glutathione, Tylenol, and Vaccines: What Parents Need to Know Lotus Homeopathy, Inc. Tylenol And Glutathione Invigor Medical Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.