Downregulation of Glutathione Mediated Detoxification Capacity by Binge Drinking Aggravates Acetaminophen Induced Liver Injury through IRE1 ER Stress Signaling Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Can I give Tylenol (acetaminophen) to a patient with elevated aspartate aminotransferase (AST) alanine aminotransferase (ALT) levels? Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Can N Acetylcysteine be Used in Non Acetaminophen Induced Acute Liver Failure? Clinical Correlations