The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model Theoretical Biology and Medical Modelling Springer Nature Link Tylenol lowers glutathione, which is why it can cause liver failure. Low glutathione can cause many serious health problems that can vary from person to person. Finding out if you have genes that can Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect Is it safe to drink while taking Tylenol?