Sensitized mast cells for targeted drug delivery and augmented cancer immunotherapy: Cell Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Did you know one single mast cell can release chemicals that affect your skin, gut, heart, brain, and immune system all at once? That's why MCAS can feel so overwhelming, the AAAAI Mast Cell Disorders Committee Work Group Report: Mast cell activation syndrome (MCAS) diagnosis and management Journal of Allergy and Clinical Immunology Real Time Monitoring of Glutathione in Living Cells Reveals that High Glutathione Levels Are Required to Maintain Stem Cell Function: Stem Cell Reports