The allergic cascade. Mast cell mediators, including cytokines, cause Download Scientific Diagram Oxidative Stress and Mitochondria Are Involved in Anaphylaxis and Mast Cell Degranulation: A Systematic Review Interplay of oxidative stress and neuroinflammation in alzheimer's: insights into age driven pathogenesis Inflammopharmacology Springer Nature Link Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Glutathione Cell Defense (Formally Recancostat 400) Mark Hyman, MD