Tylenol: How much is too much of a good thing? Allied Medical Training Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram Acetaminophen Toxicity: OPPOSITE EFFECTS OF TWO FORMS OF GLUTATHIONE PEROXIDASE ScienceDirect Tylenol's Impact on Glutathione and Liver Damage