Glutathione Benefits: The Antioxidant You've Never Heard Of Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Tylenol and Glutathione: A Closer Look At Their Relationship