Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration Clinical and Experimental Pediatrics The molecular mechanisms of acetaminophen induced hepatotoxicity and its potential therapeutic targets Guangwen Luo, Lili Huang, Zhaowei Zhang, 2023 Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Mechanism of paracetamol toxicity NUS Faculty of Science NUS Faculty of Science
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