The mechanism of action of N acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species ScienceDirect Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Tylenol Glutathione Kizer Wellness LLC Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Angel's Liquid Glutathione Niacinamide Arbutin Cooling Fresh Deodorant Amore Cosmetics