Xia & He Publishing Paracetamol Induced Hepatotoxicity , Overdose NAPQI formation Glutathione depletion Liver cell necrosis. Early N acetylcysteine (NAC) can save the liver., #Pharmacology #mbbs #Hepatotoxicity Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect Pharmacology 401 k Paracetamol NAPQI Glutathione COX3 Poisoning Antidote AcetylCysteine YouTube A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010
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paracetamol and glutathione depletion Paracetamol is one of the most commonly used analgesic and antipyretic drugs