Pigmented Lesions of the Oral Mucosa Pocket Dentistry Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Oral Melanotic Macule: Symptoms and Treatment Skinsight a Melanotic macule at the wetdry line of the lower lip. b Melanotic Download Scientific Diagram A Rare Case of Oral Mucosal Pigmentation: Differential Diagnosis and Case Presentation JCDA