Oral Melanotic Macule: Symptoms and Treatment Skinsight Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Relative frequency of solitary melanocytic lesions of the oral mucosa Buchner 2004 Journal of Oral Pathology & Medicine Wiley Online Library Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Consultant360