BPC 157 can be taken orally or subcutaneously, and for most people there is no difference in efficacy.Yes, some people will notice one works better than the other. Yes, some people will claim that What Is BPC 157? A Medical Clinic's Guide to the Body Protective Peptide, Its Uses, and What It Actually Does Perfect B ORAL vs INJECTABLE BPC 157 Not all peptides work the same way and how you take BPC 157 matters. Here's the simple breakdown: Oral BPC 157 Best for gut health & People talk about BPC 157 like it's one thing. It isn't. Oral BPC 157 stays local. It survives digestion long enough to act on the GI mucosa, then clears before it reaches systemic circulation. People talk about BPC 157 like it's one thing. It isn't. Oral BPC 157 stays local. It survives digestion long enough to act on the GI mucosa, then clears before it reaches systemic circulation.