Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Figure 1: CMAJ Tylenol is just poison. , Dr. Stanton Hom explains how a simple over the counter drug can deplete glutathione, dysregulate detox, and show up in the literature as a risk factor for autism, asthma, Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy Tylenol analogy for SBPSD members to consider