Homocysteine and MTHFR Mutations Circulation The detox gene (MTHFR) is rendered inactive when your diet is high in meat. Our diet should be 80% plant based or higher. Let's clear something up about MTHFR. You've probably heard it talked about online. Sometimes it's overhyped. Sometimes it's ignored. The truth is somewhere in the middle. MTHFR is a gene that affects Understanding Methylation, Gene Regulation and the MethylDetox Profile Alcat Education MTHFR polymorphisms in autoimmune diseases: Mechanistic and clinical perspectives ScienceDirect