Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Glucose 6 phosphate dehydrogenase deficiency Knowledge @ AMBOSS Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases G6PD Deficiency Causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( Happy Week 6! Check out the graphic to learn more about Glutathione Synthetase Deficiency.