Levothyroxine (Synthroid, Tirosint, Levoxyl) is a medication for treating hypothyroidism (underactive thyroid), a condition that is more common in people with Down syndrome. Health care providers usually recommend taking levothyroxine with water GLUTATHIONE WHAT YOU NEED TO KNOW Glutathione is a master antioxidant essential for optimizing our health. Many Americans are chronically depleted in glutathione due to: Living in a stressed state 24 7 Frontiers The protective role of nutritional antioxidants against oxidative stress in thyroid disorders Drug delivery systems for thyroid disease treatment: A mini review on current therapies and alternative approaches ScienceDirect PDF) Assessment of thiol disulfide and glutathione homeostasis after levothyroxine replacement in individuals with autoimmune or nonautoimmune hypothyroidism