Liver injury induced by paracetamol and challenges associated with intentional and unintentional use A study published in Gastroenterology describes a new mitochondrial mediator in the hepatotoxicity induced by paracetamol. Institute of Biomedical Research of Barcelona Acetaminophen Pathway (toxic doses), Pharmacokinetics Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione depletion biomarkers ophthalmic acid and 5 oxoproline in humans and rats Integrative Biology (RSC Acquired pyroglutamic acidosis due to long term dicloxacillin and paracetamol use BMJ Case Reports