NAC vs Glutathione: Comparing Antioxidant Powerhouses for Your Health IVDrips What is NAC? N acetylcysteine and its many heath benefits Altasano Individuals with MTHFR mutations and slow COMT activity can generally take N acetylcysteine (NAC) and glutathione, but there are some important considerations: ## N Acetylcysteine (NAC) * **Benefits**: NAC supports the production of glutathione, Effect of N Acetylcysteine on Sleep: Impacts of Sex and Time of Day Existing and potential therapeutic uses for N acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits ScienceDirect