Chronic acetaminophen ingestion resulting in severe anion gap metabolic acidosis secondary to 5 oxoproline accumulation: an under diagnosed phenomenon BMJ Case Reports Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Biochemistry Metabolism of acetaminophen (paracetamol) . Acetaminophen is widely used as a painkiller. Taken in the usual therapeutic doses, it is Instagram Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Liver injury induced by paracetamol and challenges associated with intentional and unintentional use