Dental Update Malignant oral melanoma: how to spot it and how it is managed Dental Update Labial Macules: Dark Spots on the Lip Dermatology Advisor Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Definition of melanocytic macules associated with Peutz Jeghers syndrome NCI Dictionary of Genetics Terms NCI Comment below