Understanding Glutathione Deficiency Invigor Medical Natural Compounds and Glutathione: Beyond Mere Antioxidants Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Frontiers Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation Glutathione: The Master Antioxidant Keeping Your Cells in Check Vitall