Does Ibuprofen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA What To Avoid When Taking Glutathione Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. What Foods to Avoid When Taking Glutathione the biostation Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology