Thioredoxin Glutaredoxin Systems and Gut Microbiota in NAFLD: Interplay, Mechanism, and Therapeutical Potential Exploring the Thioredoxin System as a Therapeutic Target in Cancer: Mechanisms and Implications Frontiers Assigning function to active site residues of Schistosoma mansoni thioredoxin glutathione reductase from analysis of transient state reductive half reactions with variant forms of the enzyme SmTGR: Thioredoxin Glutathione Reductase from Schistosoma mansoni Biocrystal Facility Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox active selenolthiol selenenylsulfide formed from the conserved cysteine selenocysteine sequence PNAS