Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Clinical Toxicology Springer Nature Link NAC vs Glutathione: Which Antioxidant Is Right for You? Momentous Before you spend money on glutathione, read this first. Topical, oral, injectable what actually works and what's just marketing? #funskincare #funingredientsinfographic101