What Caused These Multiple Hyperpigmented Macules of the Mouth? Oral Melanotic Macule: Symptoms and Treatment Skinsight Labial melanotic macule. B). Increased numbers of me lanocytes along Download Scientific Diagram An oral melanotic macule is a harmless dark spot found on the lip, most often the lower lip, or inside the mouth, either on the gums, inside the cheek, or on the roof of the mouth. An oral melanotic Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor