File:Glutathion metabolism DE state in G6PD deficiency.png Wikimedia Commons G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No G6PD Deficiency causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( Diagram showing red cell response to oxidative damage from drugs. (A). Download Scientific Diagram Understanding and Managing Glucose 6 Phosphate Dehydrogenase Deficiency ScienceDirect