Did you know that high doses of paracetamol can be toxic to your liver? Paracetamol, also known as acetaminophen, is a commonly used painkiller that can have harmful effects on the body View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, How acetaminophen is metabolized in the liver Paracetamol (acetaminophen) toxicity occurs when the liver is overwhelmed by a toxic metabolite called N acetyl p benzoquinone imine (NAPQI), which is normally detoxified by glutathione. In overdose, glutathione is depleted, and NAPQI accumulates, leading