Multifocal Pigmentation of the Oral Cavity The Journal of the American Dental Association Oral Melanotic Macule: Symptoms and Treatment Skinsight This patient has multiple labial melanotic macules. These are essentially freckles of the lips. These most commonly involve the lower lip. This patient had involvement of both the upper and lower lips. Oral Mucosal Melanosis IntechOpen Simple cryosurgical treatment of the oral melanotic macule ScienceDirect