Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology OTC, NOT RISK FREE: We're getting more calls than usual about acetaminophen, the active ingredient in Tylenol. Many over the counter (OTC) products contain a mix of pain and fever reducers, cough suppressants, and other Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Anion Gap Acidosis Associated with Acetaminophen Annals of Internal Medicine Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness?