Directly from the paper covered by the post earlier, 90 year old equivalent mouse before and after treatment with FOXO4 D reverso inversio peptide, a FOXO4 inhibitor that blocks FOXO4 from arresting senescent cell apoptosis. FOXO4 DRI improves spermatogenesis in aged mice through reducing senescence associated secretory phenotype secretion from Leydig cells ScienceDirect Frontiers FOXO4 DRI regulates endothelial cell senescence via the P53 signaling pathway Peptide inhibitors targeting FOXO4 p53 interactions and inducing senescent cancer cell specific apoptosis bioRxiv Figure 4 FOXO4 DRI alleviates age related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice Aging