This lovely patient was thrilled with her beautiful result after laser treatment of oral melanotic macules. I share this case to educate: laser treatment requires accurate diagnosis, an understanding of the differential Oral Melanotic Macule: Symptoms and Treatment Skinsight Peutz Jeghers syndrome: black spots localized in the perioral area. Download Scientific Diagram Pigmented Lesions of the Oral Cavity Oral and Maxillofacial Surgery Clinics Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in