Glutathione for the skin Paula's Choice Glutathione has to be taken daily morning empty stomach coupled with a vit C supplement for better absorption and has to be taken for 8 months to see a result. @truebasics_in @ Best taken in the morning! Take on an empty stomach for better absorption. Your body takes it in more efficiently when it's not busy digesting food. Numbuzin No.5+ Glutathione Vitamin Concentrated Serum 30ml Wondering about the best time to take your vitamins? Some are better taken in the morning, while others with a meal. Consistency is key, so take them at the same time daily.