Xia & He Publishing The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model Theoretical Biology and Medical Modelling Springer Nature Link Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration Acetaminophen, also known as Tylenol, is used to help with pain & to reduce fever. However, taking too much acetaminophen can be harmful to the liver which filters out toxins & The FDA is signaling that perhaps immediate treatment with acetaminophen is less clearly needed for a low grade fever, especially in pregnancy, unless theres a stronger indication for it., Safer