Perioral Pigmentation One Area. Many Diagnoses. Dark skin around the mouth is one of the most common concerns I see in my OPD but it is never just tanning. Smoker's melanosis Wikipedia Lip pigmentation Relationship between CD4+ count, serum inflammatory cytokines, and oral melanotic hyperpigmentation in newly diagnosed HIV seropositive patients: a nested case control study Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Pigmented Lesions of the Oral Mucosa Pocket Dentistry