Acetaminophen Anesthesia Key Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, What is Acetaminophen Uses, Dangers, Risks, & More Rubicon Acetaminophen Depletes Glutathione Essential Formulas