B12 Shots for Energy: Do They Work, Who Needs Them & What to Expect Greenwich Medical Spa How to self inject intramuscular vitamin B12 Overview Guy's and St Thomas' NHS Foundation Trust Do B12 shots actually work? Short answer YESfor the right people. Benefits may include: Increased energy Better focus Improved metabolism Especially helpful if you're deficient. If Vitamin B12 Injection: Benefits, Uses and Who Needs It Periville Pharmacy Lets do my first B12 injection together This is something Ive been nervous about for a long time, but today I finally did itand it honestly wasnt bad at all. I used the Union Medico needle guide