Cold sore triggers vary from person to person, but HSV is an opportunistic infection. That means it rears its ugly head when, for whatever reason, your immune system is too weak to HERPES VIRUSES reactivation Sequence of events** When a person is suffering from chronic stress, excess Cortisol and Adrenaline with lowered Glutathione. Glutathione is the body's most important antioxidant. Insufficient Glutathione reduces the Glutathione (GSH) as an antioxidant. Hydrogen peroxide (H2O2) and Download Scientific Diagram Using CSF Proteomics to Investigate Herpesvirus Infections of the Central Nervous System Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus Journal of Biomedical Science Springer Nature Link