Acetaminophen metabolism Paracetamol Induced Hepatotoxicity , Overdose NAPQI formation Glutathione depletion Liver cell necrosis. Early N acetylcysteine (NAC) can save the liver., #Pharmacology #mbbs #Hepatotoxicity Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Unveiling the molecular basis of paracetamol induced hepatotoxicity: Interaction of N acetyl p benzoquinone imine with mitochondrial succinate dehydrogenase ScienceDirect Mechanism of paracetamol toxicity NUS Faculty of Science NUS Faculty of Science