A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism Tylenol (acetaminophen) is one of the most commonly used painkillers. It is safe for kids, during pregnancy, and while breastfeeding. However, just because it is safe, doesn't mean that it Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function,