Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Tylenol and Glutathione: A Closer Look At Their Relationship I've posted this every year for 7 years. PSA please share. The horror stories from Tylenol (Acetaminophen) usage for children are hard to digest literally. The way my mind Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine