Does anyone know what this black mark on my lip is? Started last August so it's I've had it nearly a year, was living in Spain at the time for 6 months Clinical Challenge: Brown Macule on Lip MPR Tanning injections: do you know the dangers? Spotty lips. These are labial melanotic macules, kinda like freckles on the lips. They are mostly due to age and sun exposure, but sometimes they run in families and are associated with Melanotan II Erectile Dysfunction Studies: What Early Research Shows and Practical Realities