Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Liver injury induced by paracetamol and challenges associated with intentional and unintentional use Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen Pathway (therapeutic doses), Pharmacokinetics