Metabolism: Master the Carnitine Shuttle and Stop Exam Stress! Long Chain Fatty Acids (LCFAs) love to burn energy, but they face a major obstacle: they cannot enter the mitochondrial matrix where Beta Oxidation Short Note On Carnitine Shuttle: Fatty acids are oxidized in mitochondria, and synthesized in the cytoplasm. Long chain fatty acids must form an active intermediate, fatty acyl CoA, before being oxidized inside mitochondria. Catherine The Importance of the Fatty Acid Transporter L Carnitine in Non Alcoholic Fatty Liver Disease (NAFLD) The Role of l Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation Carnitine Acyl carnitine Carrier Encyclopedia MDPI