A pathogenic mutation in SNAP impairs membrane lipid binding by concealing a critical hydrophobic loop Communications Biology Purification of GST Be82 with glutathione Sepharose 4B beads. Shown are Download Scientific Diagram Cleaner Protein with HaloTag Purification Resins Sigma Aldrich Activated ThiolSepharose 4B, lyophilized Powder 1 G Metabolic profiling reveals pyrimidine synthesis enzyme CAD as a central carbon metabolism signaling node in cancer cell proliferation: Molecular Cell