For 20 years, it seemed "obvious" that NSAIDs blunt training adaptation. Trappe 2002 showed ibuprofen suppressed muscle protein synthesis 24 hours after exercise. Mikkelsen 2009 showed a local NSAID infusion blocked satellite Ibuprofen administration attenuates serum TNF levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation ScienceDirect What is glutathione and why must we protect patient access to it? Nonsteroidal Anti inflammatory Drugs, Acetaminophen, and COX 2 Inhibitors Anesthesia Key S) (+) Ibuprofen (Dexibuprofen) COX 1 COX 2 Inhibitor MedChemExpress